Synergetic estrogen receptor-targeting liposome nanocarriers with anti-phagocytic properties for enhanced tumor theranostics.

Abstract

Multifunctional nanocarriers have been widely applied due to their enhanced effect on tumor therapeutics. Nevertheless, owing to the natural immune clearance mechanisms in living bodies, nanocarriers tend to be eliminated during blood circulation, thereby impeding their effective arrival at the tumor sites. Herein, we constructed a synergetic targeted liposome nanocarrier system named SELS functionalized with both a tumor identification ligand (anti-ER (Estrogen Receptor) antibody) and an immune targeting ligand (Self-Peptide (SP)). The anti-ER antibody could recognize and bind ER-positive breast cancer tissues in a specific way. SP could activate the CD47-SIRPα immune response, which reduced phagocytosis of the nanoparticles by macrophages. Both the enhanced targeting ability and anti-phagocytosis behavior could improve the tumor uptake of the nanocarriers and prevent their immune clearance in living systems. Therefore, drug-loaded SELS enabled improved tumor imaging and therapeutic performance in living systems.

• Authors: Yuehua Wang, Zihua Wang, Yixia Qian, Linyang Fan, Chunyan Yue, Fei Jia, Jian Sun, Zhiyuan Hu, Weizhi Wang
• Journal: Journal of materials chemistry. B (J Mater Chem B) Vol. 7 Issue 7 Pg. 1056-1063 (02 21 2019) ISSN: 2050-7518 [Electronic] England
• PMID: 32254773 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Ligands
• Liposomes
• Peptides
• Receptors, Estrogen
• Doxorubicin

Topics

• Animals
• Antineoplastic Agents (administration & dosage, chemistry, pharmacology)
• Cell Survival (drug effects)
• Doxorubicin (administration & dosage, chemistry, pharmacology)
• Humans
• Ligands
• Liposomes (chemistry, metabolism)
• MCF-7 Cells
• Macrophages (cytology, immunology, metabolism)
• Mice
• Mice, Inbred BALB C
• Nanoparticles (chemistry, metabolism)
• Neoplasms (drug therapy, pathology)
• Peptides (chemistry, metabolism, pharmacology)
• Phagocytosis (drug effects)
• RAW 264.7 Cells
• Receptors, Estrogen (chemistry, metabolism)
• Theranostic Nanomedicine
• Transplantation, Heterologous