Tumour necrosis factor alpha (cachectin) mimics some of the effects of tumour growth on the disposal of a [14C]lipid load in virgin, lactating and litter-removed rats.

Abstract

Tumour necrosis factor alpha (cachectin) was administered to virgin, lactating and litter-removed rats, and subsequent disposal of an oral [1-14C]triolein (glycerol tri[1-14C]oleate) load examined. Absorption of the lipid and 14CO2 production were significantly depressed in all three groups. [14C]Lipid accumulation was decreased in carcass, liver and adipose tissue (brown and white) of virgin and litter-removed rats and the mammary gland of lactating rats. The plasma triacylglycerol concentration was increased in all three groups, and lipoprotein lipase activity was decreased in the white adipose tissue of virgin and litter-removed animals and in the mammary gland of lactating animals. Some, but not all, of these effects mimic tumour burden in the same physiological states [Evans & Williamson (1988) Biochem. J. 252, 65-72].

• Authors: R D Evans, D H Williamson
• Journal: The Biochemical journal (Biochem J) Vol. 256 Issue 3 Pg. 1055-8 (Dec 15 1988) ISSN: 0264-6021 [Print] England
• PMID: 3223945 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Tumor Necrosis Factor-alpha
• Triolein
• Lipoprotein Lipase

Topics

• Adipose Tissue (metabolism)
• Animals
• Female
• Hypertriglyceridemia (chemically induced)
• Lactation (metabolism)
• Lipoprotein Lipase (antagonists & inhibitors)
• Mammary Glands, Animal (metabolism)
• Neoplasms (metabolism)
• Pregnancy
• Rats
• Rats, Inbred Strains
• Triolein (pharmacokinetics)
• Tumor Necrosis Factor-alpha (pharmacology)