[Prolonged anticoagulation following chlorophacinone poisoning].

Abstract

In 1985 and 1986 the Swiss Toxicologic Information Center registered 152 cases of rodenticide poisoning. Among those substances chlorophacinone, an indanedione derivative, has a prolonged antivitamin K effect. We report here the case of an eighteen-year-old female hospitalized 3 days after deliberately ingesting some 100 mg chlorophacinone. Her Quick time at admission was less than 10% (Prothrombin time 79 sec., normal control 12 sec.). Under high dose vitamin K therapy the Quick was rapidly corrected but fell again on each vitamin K withdrawal. In a search for a relation between the variations of prothrombin time and chlorophacinone plasma levels, these were assessed by HPLC. Prothrombin time (and vitamin K dependent factors VII and X) finally normalized only 7 weeks after chlorophacinone ingestion. Clinical condition remained satisfactory throughout and other biological parameters unaffected. This case emphasizes the need for prolonged clinical and laboratory follow-up for rodenticide intoxications and for vitamin K administration for several weeks.

• Authors: J J Vogel, P de Moerloose, C A Bouvier, J Gaspoz, P Riant
• Journal: Schweizerische medizinische Wochenschrift (Schweiz Med Wochenschr) Vol. 118 Issue 50 Pg. 1915-7 (Dec 17 1988) ISSN: 0036-7672 [Print] Switzerland
• Vernacular Title: Anticoagulation prolongée lors d'une intoxication à la chlorphacinone.
• PMID: 3222685 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Anticoagulants
• Indans
• Indenes
• Rodenticides
• Vitamin K
• chlorophacinone

Topics

• Adolescent
• Anticoagulants (poisoning)
• Female
• Humans
• Indans (poisoning)
• Indenes (poisoning)
• Rodenticides (poisoning)
• Suicide, Attempted
• Time Factors
• Vitamin K (antagonists & inhibitors, therapeutic use)