In order to prevent myonephropathic
metabolic syndrome (MNMS) following acute
arterial occlusion of the extremities, the efficacy of plasma filtration to eliminate
myoglobin which causes
acute renal failure and other metabolites was evaluated by experimental model. Twenty five mongrel dogs weighing 10 to 20 kg were used. Infra-renal aorta and unilateral femoral arteries were ligated and 2/3 of the femoral muscle was carved. After 24 hrs, these
ligations were released and
thrombectomy was carried out. The dogs were divided into two groups: Group 1 was consisted of the dogs without any treatment and group 2 dogs were treated by plasma filtration. The changes in serum
myoglobin,
potassium,
lactic acid and etc. were compared between the two groups. The plasma filter was hollow-fiber type that was made of
polypropylene fiber. The serum level of
myoglobin,
potassium, CPK, GOT and BUN tended to decrease remarkably after revascularization in group 2 in contrast with those in group 1. There were statistically significant differences between the corresponding data of the two groups. Although the
lactic acid levels were lower in group 2 than group 1, those were not significant statistically. In conclusion, the application of plasma filter was effective for the treatment of
hyperkalemia and removal of
myoglobin and unknown moderate molecular weight pathogenic substances to prevent MNMS.