Abstract |
The long, noncoding RNA ( lncRNA) PVT1, as an important epigenetic regulator, has a critical role in carcinogenesis. However, its role in pancreatic ductal adenocarcinoma (PDAC) has not been fully investigated. Here, the up-regulated expression of lncRNA PVT1 is found in our PDAC tumor samples. Knockdown of it suppressed PDCA cells growth and glycolysis. An inverse association between miR-519d-3p and PVT1 was found. RIP, RNA pulldown and luciferase assay showed that PVT1 directly targets miR-519d-3p by binding with microRNA binding site. Bioinformatics analysis and study indicated that HIF-1A is a target of miR-519d-3p. Collectively, our findings suggested that PVT1 could act as an oncogenic lncRNA, and promote tumor progression by regulating HIF-1A via competing with miR-519d-3p.
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Authors | Junwei Sun, Pingping Zhang, Tao Yin, Feng Zhang, Weixing Wang |
Journal | Journal of Cancer
(J Cancer)
Vol. 11
Issue 9
Pg. 2572-2579
( 2020)
ISSN: 1837-9664 [Print] Australia |
PMID | 32201527
(Publication Type: Journal Article)
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Copyright | © The author(s). |