Abstract | OBJECTIVE: STUDY DESIGN: The clinicopathologic data and follow-up information of 167 post- hysterectomy vaginal HSIL patients who underwent laser ablation or vaginectomy were retrospectively reviewed from 2010 to 2018 at the Obstetrics and Gynecology Hospital of Fudan University. RESULTS: Of the 167 vaginal HSIL patients enrolled, 74 patients underwent vaginectomy, and 93 patients underwent laser ablation. At a median follow-up of 15 months, 13 (7.8 %) patients experienced progression to vaginal cancer, and 22 (13.2 %) patients had persistent/recurrent disease. Upon multivariate analysis, laser ablation (OR: 5.16, p = 0.02), cytology indicating HSIL (OR: 25.45, p = 0.00), and a shorter interval between previous hysterectomy and vaginal HSIL diagnosis (< 24 vs ≥ 24 months, OR: 0.10, p = 0.02) were associated with disease persistence/recurrence. In post- hysterectomy for cervical HSIL patients, the vaginectomy group had a significantly higher recurrence-free survival rate (RFS, 94.5 % vs 69.0 %, p = 0.00) and a similar progression-free survival rate (PFS, 96.4 % vs 91.4 %, p = 0.17) compared with the laser ablation group. Among post- hysterectomy for cervical cancer patients, RFS (89.5 % vs 65.7 %, p = 0.04) and PFS (100.0 % vs 82.9 %, p = 0.05) were both higher in the vaginectomy group than in the laser ablation group. CONCLUSION:
|
Authors | Fang Shen, Shu-Gen Sun, Xu-Yin Zhang, Qing Wang, Jing-Xin Ding, Ke-Qin Hua |
Journal | European journal of obstetrics, gynecology, and reproductive biology
(Eur J Obstet Gynecol Reprod Biol)
Vol. 248
Pg. 71-76
(May 2020)
ISSN: 1872-7654 [Electronic] Ireland |
PMID | 32199295
(Publication Type: Comparative Study, Journal Article)
|
Copyright | Copyright © 2020. Published by Elsevier B.V. |
Topics |
- Aged
- Carcinoma, Squamous Cell
(surgery)
- Female
- Humans
- Hysterectomy
(statistics & numerical data)
- Laser Therapy
(statistics & numerical data)
- Middle Aged
- Neoplasm Recurrence, Local
(surgery)
- Retrospective Studies
- Squamous Intraepithelial Lesions of the Cervix
(surgery)
- Uterine Cervical Neoplasms
(surgery)
- Vaginal Neoplasms
(diagnosis, surgery)
|