Abstract | AIM: To perform a systematic review and meta-analysis of randomized controlled trials (RCTs) to evaluate the effect of probiotics in pregnancy on the incidence of gestational diabetes (GDM) and fasting plasma glucose (FPG). METHODS: A MEDLINE, EMBASE, Scopus and Cochrane search (up to May 30th, 2019) was performed to identify RCTs of comparison of probiotics with placebo/active comparators in pregnant women. Principal endpoints were the incidence of GDM and the change of FPG. Other maternal and fetal outcomes were secondary endpoints. Mantel-Haenszel Odds Ratio with 95% CI (MH-OR) was calculated for dichotomous outcomes, whereas standardized differences in means was calculated for continuous variables. (PROSPERO registration CRD42019139889). FINDINGS: A total of 17 RCTs, all versus placebo, was identified. The overall quality of the trials was satisfactory. No effect of probiotics on incidence of GDM (MH-OR: 0.77[0.51,1.16], p = 0.21,I2:62%) was observed, with a small but significant reduction of FPG (mean difference -1.01 [-1.96, -0.06]mg/dl, p = 0.02, I2:46%). Among secondary endpoints, a significant reduction of maternal insulin (both in women with or without diabetes) was observed in the probiotics group. INTERPRETATION: Probiotics during pregnancy do not reduce the incidence of GDM, with a very little (statistically but not clinically significant) reduction of fasting plasma glucose.
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Authors | Maria Masulli, Ester Vitacolonna, Federica Fraticelli, Giuseppe Della Pepa, Edoardo Mannucci, Matteo Monami |
Journal | Diabetes research and clinical practice
(Diabetes Res Clin Pract)
Vol. 162
Pg. 108111
(Apr 2020)
ISSN: 1872-8227 [Electronic] Ireland |
PMID | 32194215
(Publication Type: Journal Article, Meta-Analysis, Systematic Review)
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Copyright | Copyright © 2020. Published by Elsevier B.V. |
Chemical References |
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Topics |
- Diabetes, Gestational
(prevention & control)
- Female
- Glucose
(metabolism)
- Humans
- Pregnancy
- Probiotics
(pharmacology, therapeutic use)
- Randomized Controlled Trials as Topic
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