Abstract |
The Aβ peptides causally associated with Alzheimer disease have been seen as seemingly purposeless species produced by intramembrane cleavage under both physiological and pathological conditions. However, it has been increasingly suggested that they could instead constitute an ancient, highly conserved effector component of our innate immune system, dedicated to protecting the brain against microbial attacks. In this antimicrobial protection hypothesis, Aβ aggregation would switch from an abnormal stochastic event to a dysregulated innate immune response. In this perspective, we approach the problem from a different and complementary perspective by comparing the structure and sequence of Aβ(1-42) with those of bona fide antimicrobial peptides. We demonstrate that Aβ(1-42) bears convincing structural similarities with both viral fusion domains and antimicrobial peptides, as well as sequence similarities with a specific family of bacterial bacteriocins. We suggest a model of the mechanism by which Aβ peptides could elicit the immune response against microbes.
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Authors | Annalisa Pastore, Francesco Raimondi, Lawrence Rajendran, Piero Andrea Temussi |
Journal | Communications biology
(Commun Biol)
Vol. 3
Issue 1
Pg. 135
(03 19 2020)
ISSN: 2399-3642 [Electronic] England |
PMID | 32193491
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Amyloid beta-Peptides
- Peptide Fragments
- Pore Forming Cytotoxic Proteins
- Protein Aggregates
- amyloid beta-protein (1-42)
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Topics |
- Alzheimer Disease
(immunology, metabolism, pathology)
- Amyloid beta-Peptides
(chemistry, metabolism)
- Animals
- Bacteria
(immunology, pathogenicity)
- Brain
(immunology, metabolism, pathology)
- Databases, Protein
- Host-Pathogen Interactions
- Humans
- Immunity, Innate
- Models, Molecular
- Peptide Fragments
(chemistry, metabolism)
- Pore Forming Cytotoxic Proteins
(chemistry, metabolism)
- Protein Aggregates
- Protein Aggregation, Pathological
- Protein Conformation
- Structure-Activity Relationship
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