BACKGROUND Congenital
factor X deficiency is a rare inherited coagulopathy. Pregnancies in women with this disorder are often associated with adverse outcomes, including
miscarriage,
premature labor, and
hemorrhage during pregnancy and in the peripartum period. The literature on this disorder is sparse and shows a limited number of successful pregnancies in women with
factor X deficiency. CASE REPORT In this report, we present the case of a successful pregnancy and term delivery by elective
cesarean section in a 39-year-old primigravida with congenital
factor X deficiency. Medical management followed the recommendations of an interdisciplinary team comprising specialists in obstetrics,
anesthesia, transfusion medicine, hematology, and neonatology. This high-risk pregnancy was successfully brought to term, and a healthy male neonate was delivered by elective
cesarean section at 39 weeks' gestation. The patient's
factor X deficiency (0.19 kIU/L) was treated using 4 units of
solvent-
detergent-treated fresh frozen plasma (SD-FFP) 1 h before the
cesarean section, leading to
hemostatic levels of
factor X and an uneventful intraoperative course. Postoperatively, the patient's
factor X levels were controlled daily and corrected using SD-FFP as needed, with no clinically significant blood loss. CONCLUSIONS SD-FFP can be used to manage congenital
factor X deficiency in the peripartum period and maintain perioperative blood loss within normal limits.