Erythromycin-induced immune hemolytic anemia.

Abstract

A 3-year-old female receiving Pediazole (erythromycin ethylsuccinate and sulfisoxazole) for tonsillitis and otitis media developed severe hemolytic anemia. No serum drug-dependent antibodies could be demonstrated with an in vitro 'immune-complex' method using Pediazole, pure erythromycin ethylsuccinate or pure sulfisoxazole. However, a method using red cells coated with erythromycin base showed in vitro lysis of the erythromycin-coated red cells. This is only the second case of immune hemolytic anemia associated with erythromycin and the first where in vitro drug-dependent hemolysis was demonstrable.

• Authors: S J Nance, S Ladisch, T L Williamson, G Garratty
• Journal: Vox sanguinis (Vox Sang) Vol. 55 Issue 4 Pg. 233-6 ( 1988) ISSN: 0042-9007 [Print] England
• PMID: 3218168 (Publication Type: Case Reports, Journal Article)

Chemical References

• Erythromycin

Topics

• Anemia, Hemolytic (chemically induced, immunology)
• Child, Preschool
• Erythrocytes (drug effects)
• Erythromycin (adverse effects)
• Female
• Humans