Erythema multiforme is associated to HLA-Aw33 and DRw53.

Abstract

Erythema multiforme is an acute eruption of the skin and mucous membranes of various aetiologies. Forty-one unrelated patients were HLA typed for 53 specificities of the HLA-A, B, C, DR and DQ series. Frequencies of Aw33 and DRw53 were significantly increased: Aw33, 17.0% in patients vs 2.8% in controls (corrected p = 0.01, relative risk = 7.2); DRw53, 70.7% in patients vs 30.5% in controls (corrected p = 0.0005, relative risk = 5.5).

• Authors: V Lepage, C Douay, C Mallet, O Binet, F Lemarchand, D Wallach, M Masset, J Colombani, L Degos
• Journal: Tissue antigens (Tissue Antigens) Vol. 32 Issue 3 Pg. 170-5 (Sep 1988) ISSN: 0001-2815 [Print] England
• PMID: 3217933 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• HLA-A Antigens
• HLA-A*33 antigen
• HLA-DR Antigens
• HLA-DR53
• HLA-DRB4 Chains

Topics

• Adult
• Aged
• Aged, 80 and over
• Erythema Multiforme (genetics, immunology, physiopathology)
• Female
• Gene Frequency
• HLA-A Antigens (immunology)
• HLA-DR Antigens (immunology)
• HLA-DRB4 Chains
• Humans
• Male
• Middle Aged
• Phenotype