[Polyamines as a prognostic criterion of the duration of clinico-hematologic remission in acute leukemia in children].

Abstract

The authors reported the results of retrospective analysis of the level of polyamines in urine and the duration of clinicohematological remission in 25 AL children aged 3 to 14. Of this number 23 patients suffered from acute lymphoblastic leukemia, 2--from acute myeloblastic leukemia. Direct correlation between polyamine changes during a course of chemotherapy and the duration of remission was established. Longer duration was observed in the patients in whom a 2-fold rise of the level of all polyamines, especially spermidine, followed the administration of a cytostatic within the first 24-72 h. On the discontinuation of therapy a certain decrease in polyamine excretion with urine was observed in these children as compared to the level determined on their admission to hospital.

• Authors: M E Kovtunova, L D Voronchikhina, T I Riabova, N V Riabov
• Journal: Terapevticheskii arkhiv (Ter Arkh) Vol. 60 Issue 9 Pg. 77-9 ( 1988) ISSN: 0040-3660 [Print] Russia (Federation)
• Vernacular Title: Poliaminy kak prognosticheskiĭ kriteriĭ dlitel'nosti kliniko-gematologicheskoĭ remissii pri ostrom leĭkoze u deteĭ.
• PMID: 3217885 (Publication Type: English Abstract, Journal Article)

Chemical References

• Polyamines

Topics

• Adolescent
• Child
• Child, Preschool
• Humans
• Leukemia, Myeloid, Acute (blood, drug therapy)
• Polyamines (urine)
• Precursor Cell Lymphoblastic Leukemia-Lymphoma (blood, drug therapy)
• Predictive Value of Tests
• Prognosis
• Remission Induction
• Retrospective Studies