[Problems of pathogenesis of ovarian and idiopathic hirsutism].

Abstract

The content of total testosterone (T), dehydrotestosterone (DHT), androstenedione (A), estradiol (E2), luteotropin (LH) and follicle-stimulating hormone (FSH) was studied in patients with ovarian and idiopathic hirsutism by a radioimmunoassay. The level of T-E-binding globulin (TEBG) was determined by 3H-DHT binding. Concentrations of free and TEBG-unbound T, DHT and E2 were calculated on the basis of the mass action law. The level of free and TEBG-unbound T and DHT was found to be the most reliable marker of the excessive production of androgens in hirsutism. The level of total T and DHT was raised in 50-60% of patients with hirsutism. Patients with hirsutism of ovarian genesis were characterized by considerable blood elevation of LH and FSH with still greater values in patients with menstrual disturbance, and by a rise of an A level. Difference found in hormonal indices can be used in differential diagnosis of ovarian and idiopathic hirsutism.

• Authors: L V Tarasenko, A G Reznikov, E A Benikova, S V Varga, D I Derevianko
• Journal: Problemy endokrinologii (Probl Endokrinol (Mosk)) 1988 Sep-Oct Vol. 34 Issue 5 Pg. 28-32 ISSN: 0375-9660 [Print] Russia (Federation)
• Vernacular Title: Voprosy patogeneza ovarial'nogo i idiopaticheskogo girsutizma.
• PMID: 3217384 (Publication Type: English Abstract, Journal Article)

Chemical References

• Hormones

Topics

• Adolescent
• Adult
• Female
• Hirsutism (blood, etiology)
• Hormones (blood)
• Humans
• Ovarian Diseases (complications)