HLA antigen frequencies in HIV-1 seropositive disease-free individuals and patients with AIDS.

Abstract

HLA-A, -B, -C, -DR, and -DQ antigen phenotypes were determined in 266 Caucasian homosexual men, 90 of whom were HIV-1 seronegative, 94 HIV-1 seropositive AIDS-free, and 82 with a diagnosis of AIDS [36 with Kaposi's sarcoma (KS), 34 with opportunistic infection (OI), and 12 with KS and OI]. No significant differences in HLA-A or -B antigen frequencies were found in any comparisons of these groups. However, in comparisons of seropositive AIDS-free men with the AIDS groups, HLA-Cw7 was increased in frequency in OI and HLA-DR1, -DRw14, and -DQw1 in KS. HLA-DR3 and -DQw3 frequencies were decreased in KS, and DRw53 was decreased in OI. In a cohort of 102 HIV seropositive individuals that were followed for a mean of 43 months, AIDS developed in HLA-DR1 positive men more frequently than in individuals with other HLA-DR phenotypes (p = 0.02). These results demonstrate probable genetic differences between individuals developing KS and OI and indicate that the HLA-DR1 phenotype is a risk factor in disease progression in human immunodeficiency virus (HIV)-infected individuals.

• Authors: D L Mann, C Murray, R Yarchoan, W A Blattner, J J Goedert
• Journal: Journal of acquired immune deficiency syndromes (J Acquir Immune Defic Syndr (1988)) Vol. 1 Issue 1 Pg. 13-7 ( 1988) ISSN: 0894-9255 [Print] United States
• PMID: 3216293 (Publication Type: Journal Article)

Chemical References

• HLA Antigens
• HLA-A Antigens
• HLA-B Antigens
• HLA-C Antigens
• HLA-DQ Antigens
• HLA-DR Antigens

Topics

• Acquired Immunodeficiency Syndrome (complications, immunology)
• HIV Seropositivity (immunology)
• HIV-1
• HLA Antigens (analysis)
• HLA-A Antigens (analysis)
• HLA-B Antigens (analysis)
• HLA-C Antigens (analysis)
• HLA-DQ Antigens (analysis)
• HLA-DR Antigens (analysis)
• Humans
• Male
• Opportunistic Infections (complications, immunology)
• Sarcoma, Kaposi (etiology, immunology)