The effect of a new gastric proton pump inhibitor on serotonin-induced gastric mucosal lesions in rats.

Abstract

The anti-ulcer effect of NC-1300, a new proton pump inhibitor, and its effect on gastric mucosal blood flow were studied in rats. Acute gastric mucosal lesions were induced by the subcutaneous administration of serotonin, 20 mg/kg. Using the electrolytically generated hydrogen gas clearance technique, it was determined that such gastric ulceration resulted mainly from a decrease in gastric mucosal blood flow. These lesions could be inhibited to a statistically significant extent by the intravenous administration of NC-1300, 20 mg/kg, which markedly inhibited gastric acid secretion. However, the serotonin-induced decrease in gastric mucosal blood flow could not be prevented by pretreatment with 20 mg/kg of NC-1300. It was concluded that protection against serotonin-induced gastric ulceration can be achieved by markedly inhibiting gastric acid secretion.

• Authors: Y Tsukamoto, S Nakazawa, K Segawa, H Goto, A Fukui, K Takano, S Hase, T Arisawa, T Osada, Y Kawabe
• Journal: Gastroenterologia Japonica (Gastroenterol Jpn) Vol. 23 Issue 5 Pg. 501-5 (Oct 1988) ISSN: 0435-1339 [Print] Japan
• PMID: 3215434 (Publication Type: Journal Article)

Chemical References

• 2-Pyridinylmethylsulfinylbenzimidazoles
• Anti-Ulcer Agents
• Benzimidazoles
• 2-((2-dimethylaminobenzyl)sulfinyl)benzimidazole
• Serotonin
• Omeprazole

Topics

• 2-Pyridinylmethylsulfinylbenzimidazoles
• Animals
• Anti-Ulcer Agents (pharmacology)
• Benzimidazoles (pharmacology)
• Gastric Juice (metabolism)
• Gastric Mucosa (blood supply, drug effects)
• Male
• Omeprazole (analogs & derivatives)
• Peptic Ulcer (chemically induced, physiopathology)
• Rats
• Rats, Inbred Strains
• Regional Blood Flow (drug effects)
• Serotonin (administration & dosage)