[Immune status in infantile autism. Correlation between the immune status, autistic symptoms and levels of serotonin].

Abstract

In sixteen autistic children high values of IgG and a high level of lymphocyte stimulation with PHA were observed. Principal component analysis showed: 1) a significant correlation between basic lymphocyte mitogenic activity and the clinical symptoms opposition and hyperactivity, 2) a significant correlation between high Ig levels, high PHA stimulation responses and the main autistic symptoms (withdrawal, inaffectivity, hypoactivity, mannerism, stereotypy and negatively echolalia), 3) a significant correlation with serotonin uptake by platelets and high immunological responses. Such correlations are strongly in favor of an immunologic component in autistic disease.

• Authors: P Ferrari, M R Marescot, R Moulias, C Bursztejn, A Deville Chabrolle, M Thiollet, B Lesourd, A Braconnier, C Dreux, E Zarifian
• Journal: L'Encephale (Encephale) 1988 Sep-Oct Vol. 14 Issue 5 Pg. 339-44 ISSN: 0013-7006 [Print] France
• Vernacular Title: Etat immunitaire dans l'autisme infantile. Corrélations entre état immunitaire, symptômes autistiques et taux de sérotonine.
• PMID: 3215138 (Publication Type: Comparative Study, English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Immunoglobulin G
• Immunoglobulin M
• Immunoglobulins
• Phytohemagglutinins
• Serotonin

Topics

• Adolescent
• Autistic Disorder (blood, immunology, psychology)
• Blood Platelets (metabolism)
• Child
• Child, Preschool
• Female
• Humans
• Immunoglobulin G (analysis)
• Immunoglobulin M (analysis)
• Immunoglobulins (analysis)
• Lymphocyte Activation
• Male
• Phytohemagglutinins (pharmacology)
• Serotonin (blood)