[Function of the sympathetico-adrenal system and the acid-base equilibrium in newborn infants with a hypoxic lesion of the central nervous system].

Abstract

The function of the sympathetic-adrenal system was studied by measuring umbilical cord blood catecholamines in 31 full-term newborns with perinatal asphyxia and evidence of hypoxic-ischemic encephalopathy (HIE) and in 20 normal newborns. The results indicate that the full-term newborn responds to asphyxia with graded catecholamine release. The epinephrine concentration in newborns with moderate HIE is lower than in newborns with mild HIE, which may reflect decreased sympathetic-adrenal function due to prolonged asphyxia. Acid-base values in capillary blood and lumbar cerebrospinal fluid were determined in the babies with HIE, with the findings pointing to metabolic acidosis which was more expressed in cerebrospinal fluid.

• Authors: M Ia Mialksoo, T A Tal'vik, A Iu Paiu, A E Kaasik, A G Sëzt
• Journal: Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952) (Zh Nevropatol Psikhiatr Im S S Korsakova) Vol. 88 Issue 10 Pg. 52-4 ( 1988) ISSN: 0044-4588 [Print] Russia (Federation)
• Vernacular Title: Sostoianie simpatiko-adrenalovoĭ sistemy i kislotno-shchelochnogo ravnovesiia u novorozhdennykh s gipoksicheskim porazheniem tsentral'nĭ nervnoĭ sistemy.
• PMID: 3213331 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Norepinephrine
• Epinephrine

Topics

• Acid-Base Equilibrium
• Adrenal Glands (physiopathology)
• Asphyxia Neonatorum (blood, complications, physiopathology)
• Central Nervous System Diseases (blood, etiology, physiopathology)
• Epinephrine (blood)
• Fetal Blood (analysis)
• Humans
• Infant, Newborn
• Norepinephrine (blood)
• Sympathetic Nervous System (physiopathology)