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Joint American Academy of Dermatology-National Psoriasis Foundation guidelines of care for the management of psoriasis with systemic nonbiologic therapies.

Abstract
Psoriasis is a chronic inflammatory disease involving multiple organ systems and affecting approximately 2% of the world's population. In this guideline, we focus the discussion on systemic, nonbiologic medications for the treatment of this disease. We provide detailed discussion of efficacy and safety for the most commonly used medications, including methotrexate, cyclosporine, and acitretin, and provide recommendations to assist prescribers in initiating and managing patients on these treatments. Additionally, we discuss newer therapies, including tofacitinib and apremilast, and briefly touch on a number of other medications, including fumaric acid esters (used outside the United States) and therapies that are no longer widely used for the treatment of psoriasis (ie, hydroxyurea, leflunomide, mycophenolate mofetil, thioguanine, and tacrolimus).
AuthorsAlan Menter, Joel M Gelfand, Cody Connor, April W Armstrong, Kelly M Cordoro, Dawn M R Davis, Boni E Elewski, Kenneth B Gordon, Alice B Gottlieb, Daniel H Kaplan, Arthur Kavanaugh, Matthew Kiselica, Dario Kivelevitch, Neil J Korman, Daniela Kroshinsky, Mark Lebwohl, Craig L Leonardi, Jason Lichten, Henry W Lim, Nehal N Mehta, Amy S Paller, Sylvia L Parra, Arun L Pathy, Elizabeth Farley Prater, Robert S Rahimi, Reena N Rupani, Michael Siegel, Benjamin Stoff, Bruce E Strober, Elliot B Tapper, Emily B Wong, Jashin J Wu, Vidhya Hariharan, Craig A Elmets
JournalJournal of the American Academy of Dermatology (J Am Acad Dermatol) Vol. 82 Issue 6 Pg. 1445-1486 (Jun 2020) ISSN: 1097-6787 [Electronic] United States
PMID32119894 (Publication Type: Journal Article, Practice Guideline)
CopyrightCopyright © 2020 American Academy of Dermatology, Inc. All rights reserved.
Chemical References
  • Piperidines
  • Pyrimidines
  • Thalidomide
  • Cyclosporine
  • tofacitinib
  • Acitretin
  • apremilast
  • Methotrexate
Topics
  • Acitretin (therapeutic use)
  • Cyclosporine (therapeutic use)
  • Drug Monitoring
  • Humans
  • Methotrexate (therapeutic use)
  • Piperidines (therapeutic use)
  • Psoriasis (drug therapy)
  • Pyrimidines (therapeutic use)
  • Thalidomide (analogs & derivatives, therapeutic use)

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