Abstract | BACKGROUND AND PURPOSE: MATERIALS AND METHODS: In this retrospective study with a prospective skin biopsy phase, patients with estimated glomerular filtration rates of <60 mL/min/1.73 m2 undergoing contrast-enhanced MR imaging from July 2007 through June 2014 were screened for nephrogenic systemic fibrosis using a questionnaire. This was highly sensitive but not specific and reliably excluded nephrogenic systemic fibrosis if responses to at least 6 of the 8 questions were negative. If no nephrogenic systemic fibrosis was detected, a skin biopsy was requested. RESULTS: Of 2914 patients who met these criteria, 1988 were excluded for various reasons. Of the remaining 926 patients, 860 were screened negative for nephrogenic systemic fibrosis. Of these, 17 (2%) had estimated glomerular filtration rates of <15 mL/min/1.73 m2, 51 (6%) had levels of 15 < 30 mL/min/1.73 m2, 234 (27%) had levels of 30 < 45 mL/min/1.73 m2, and 534 (62%) had levels of 45 < 60 mL/min/1.73 m2. Of the 66 who were not cleared of nephrogenic systemic fibrosis by the questionnaire, 6 patients were evaluated by a dermatologist and confirmed not to have nephrogenic systemic fibrosis (no biopsy required). CONCLUSIONS: A diagnosis of nephrogenic systemic fibrosis was excluded in 860 patients with impaired renal function who were followed up and received gadobenate during MR imaging. In 14 such patients who underwent at least 1 gadobenate-enhanced MR imaging examination and did not have nephrogenic systemic fibrosis, gadolinium levels in the skin were exceedingly low.
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Authors | E Kanal, T J Patton, I Krefting, C Wang |
Journal | AJNR. American journal of neuroradiology
(AJNR Am J Neuroradiol)
Vol. 41
Issue 3
Pg. 393-399
(03 2020)
ISSN: 1936-959X [Electronic] United States |
PMID | 32115422
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Copyright | © 2020 by American Journal of Neuroradiology. |
Chemical References |
- Contrast Media
- Gadolinium
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Topics |
- Adult
- Contrast Media
(adverse effects, analysis)
- Female
- Gadolinium
(adverse effects, analysis)
- Humans
- Magnetic Resonance Imaging
(methods)
- Male
- Middle Aged
- Nephrogenic Fibrosing Dermopathy
(chemically induced, epidemiology)
- Skin
(chemistry, drug effects)
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