[Immunotherapy with CAR-T cells in paediatric haematology-oncology].

Abstract

Despite being a rare disease, cancer is the first cause of mortality due to disease during the paediatric age in the developed countries. The current, great increase in new treatments, such as immunotherapy, constitutes a new clinical and regulatory paradigm. Cellular immunotherapy is one of these types of immunotherapy. In particular, the advanced therapy drugs with chimeric antigen receptors in the T-lymphocytes (CAR-T), and particularly the CAR-T19 cells, has opened up a new scenario in the approach to haematology tumours like acute lymphoblastic leukaemia and the B-Cell lymphomas. The approval of tisagenlecleucel and axicabtagene ciloleucel by the regulatory authorities has led to the setting up of the National Plan for Advanced Therapies-CAR-T drugs in Spain. There is evidence of, not only the advantage of identifying the centres most suitable for their administration, but also the need for these to undergo a profound change in order that their healthcare activity is extended, in some cases, to the ability for the in-house manufacture of these types of therapies. The hospitals specialised in paediatric haematology-oncology thus have the challenge of progressing towards a healthcare model that integrates cellular immunotherapy, having the appropriate capacity to manage all aspects relative to their use, manufacture, and administration of these new treatments.

• Authors: Isabel Mirones, Lucas Moreno, Ana Patiño-García, Garbiñe Lizeaga, José M Moraleda, María Luisa Toribio, Antonio Pérez-Martínez, Grupo de Inmunoterapia y Terapias Avanzadas de la Sociedad Española de Hematología y Oncología Pediátricas, Grupo de Inmunoterapia y Terapias Avanzadas de la Sociedad Española de Hematología y Oncología Pediátricas
• Journal: Anales de pediatria (An Pediatr (Engl Ed)) Vol. 93 Issue 1 Pg. 59.e1-59.e10 (Jul 2020) ISSN: 2341-2879 [Electronic] Spain
• Vernacular Title: Inmunoterapia con células CAR-T en hematooncología pediátrica.
• PMID: 32107177 (Publication Type: Journal Article)
• Copyright: Copyright © 2020 Asociación Española de Pediatría. Publicado por Elsevier España, S.L.U. All rights reserved.

Chemical References

• Antigens, CD19
• Antineoplastic Agents, Immunological
• Biological Products
• Receptors, Antigen, T-Cell
• Receptors, Chimeric Antigen
• tisagenlecleucel
• axicabtagene ciloleucel

Topics

• Antigens, CD19 (therapeutic use)
• Antineoplastic Agents, Immunological (therapeutic use)
• Biological Products
• Child
• Hematology
• Humans
• Immunotherapy, Adoptive (methods)
• Lymphoma, B-Cell (therapy)
• Medical Oncology
• Pediatrics
• Precursor Cell Lymphoblastic Leukemia-Lymphoma (therapy)
• Receptors, Antigen, T-Cell (therapeutic use)
• Receptors, Chimeric Antigen (therapeutic use)
• Societies, Medical
• Spain