[Effect of oxoplatin and platidiam on human melanoma strains and functional activity of blood lymphocytes in athymic mice].

Abstract

Oxoplatinum (USSR) caused a more pronounced anticancer effect than platidiam (CSSR) when treating nude mice with the transplantable human melanoma. Moderate lymphopenia was found with therapeutic doses of oxoplatinum and platidiam, but there was no direct inhibition of the energy metabolism of lymphocytes in the peripheral blood. In the cancer cells and in the lymphocytes infiltrating the tumour oxoplatinum caused a significant decrease in the alpha-GPDG activity realizing the binding of the glycolysis and oxidation which might evidence for a definite selective action of oxoplatinum on the human melanoma.

• Authors: I K Bukharova, L I Osokina, E S Revazova
• Journal: Eksperimental'naia onkologiia (Eksp Onkol) Vol. 10 Issue 5 Pg. 55-7 ( 1988) ISSN: 0204-3564 [Print] Ukraine
• Vernacular Title: Deĭstvie oksoplatiny i platidiama na shtammy melanomy cheloveka i funktsional'nuiu aktivnost' limfotsitov krovi u bectimusnykh mysheĭ.
• PMID: 3208691 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Cisplatin
• diamminedichlorodihydroxyplatinum IV

Topics

• Animals
• Cisplatin (analogs & derivatives, pharmacology, therapeutic use)
• Leukocyte Count
• Lymphocytes (drug effects, enzymology)
• Melanoma, Experimental (blood, drug therapy)
• Mice
• Mice, Inbred BALB C
• Mice, Nude
• Tumor Cells, Cultured