Chromosomal aberrations induced by secondary and tertiary amine-containing dyes and in combination with nitrite in vivo in mice.

Abstract

Chromosomal aberrations induced by indigo carmine (secondary amine-containing dye), fast green FCF (tertiary amine-containing dye) and sodium nitrite, singly and in combination, were studied in mice after prolonged feeding in the diet. A significant increase in the chromosomal aberrations was observed for all the dyes and in the nitrite treated series when compared with distilled water controls. However, a combination of half the concentration of dye and nitrite gave additive effects.

• Authors: S K Das, A K Giri
• Journal: Cytobios (Cytobios) Vol. 54 Issue 216 Pg. 25-9 ( 1988) ISSN: 0011-4529 [Print] England
• PMID: 3208541 (Publication Type: Journal Article)

Chemical References

• Coloring Agents
• Nitrites
• Rosaniline Dyes
• Fast Green
• Indigo Carmine

Topics

• Animals
• Bone Marrow (pathology)
• Chromosome Aberrations
• Coloring Agents (analysis, pharmacology)
• Indigo Carmine (analysis, pharmacology)
• Male
• Mice
• Mice, Inbred Strains
• Nitrites (pharmacology)
• Rosaniline Dyes (analysis, pharmacology)