Preoperative intra-arterial chemotherapy with docetaxel, cisplatin, and peplomycin combined with intravenous chemotherapy using 5-fluorouracil for oral squamous cell carcinoma.

Abstract	The objectives of this study were to evaluate survival in 141 patients with stage II-IV oral squamous cell carcinoma (OSCC) treated with preoperative intra-arterial chemotherapy with docetaxel, cisplatin, and peplomycin combined with intravenous chemotherapy using 5-fluorouracil (IADCPIVF) via the superficial temporal artery, and to clarify the prognostic factors. The study population included 59 patients with stage II OSCC, 34 with stage III, and 48 with stage IV. After IADCPIVF, 139 patients underwent surgery; minimally invasive surgeries (MIS) including excisional biopsy were performed on 96 patients with a remarkably good response to IADCPIVF. The primary tumour response rate was 99.3% (complete response rate 56.7%, good partial response rate 17.0%, fair partial response rate 25.5%). Additionally, there were no serious adverse events associated with IADCPIVF. The 5-year overall survival rate was 74.6% (stage II 83.6%, stage III 72.7%, stage IV 64.8%). In the multivariate analysis of survival, T classification and clinical tumour response were significant prognostic factors. Eight (8.3%) of the patients who received MIS had primary recurrence and six were salvaged. In conclusion, IADCPIVF is safe and efficacious for treating OSCC, and MIS could reduce the extent of primary tumour resection in the case of a remarkably good response.
Authors	H Hasegawa, T Kaneko, C Kanno, M Endo, M Yamazaki, T Kitabatake, T Monma, E Takeishi, E Sato, M Kano
Journal	International journal of oral and maxillofacial surgery (Int J Oral Maxillofac Surg) Vol. 49 Issue 8 Pg. 984-992 (Aug 2020) ISSN: 1399-0020 [Electronic] Denmark
PMID	32070653 (Publication Type: Journal Article)
Copyright	Copyright © 2020 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
Chemical References	Taxoids Docetaxel Peplomycin Cisplatin Fluorouracil
Topics	Antineoplastic Combined Chemotherapy Protocols Carcinoma, Squamous Cell Cisplatin (therapeutic use) Docetaxel Fluorouracil Humans Mouth Neoplasms (drug therapy) Neoplasm Recurrence, Local Peplomycin (therapeutic use) Taxoids (therapeutic use)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!