Chlorocarbamate-mustard-linked 1,1,2-triphenylbut-1-enes with a selective antitumor activity on mammary tumors containing estrogen receptors.

Abstract

A 1,1,2-triphenylbut-1-ene with a 4-OH group at one C-1 phenyl ring and a chlorocarbamate mustard moiety at the second C-1 ring (compound 3) was synthesized in order to obtain a "cytotoxic estrogen" with a specific antitumor effect on estrogen-receptor-containing tumors. This compound was tested in comparison to the carrier (compound 1) and a compound (2) having a carbamate mustard group on both C-1 phenyl rings. The estrogen receptor affinity of compound 3 was only about one-quarter lower than that of compound 1, but much higher than that of compound 2. Compounds 2 and 3 showed only partially irreversible binding to the receptor owing to their relatively low alkylating properties. The growth inhibition of the receptor-positive MCF-7 breast cancer cell line by compound 3, but not by compound 1 or 2, was more pronounced than the inhibition of the receptor-negative line MDA. In vivo the hormone-dependent, transplantable mammary tumor MXT M3.2 of the mouse was much better inhibited by compound 3 than its hormone-resistent line MXT OVEX. Compounds 1-3 had no antiestrogenic properties in the mouse, but estrogenic activity was in the order 1 greater than 3 greater than 2. From these results and because the antitumor activity of compound 3 was superior to that of compounds 1 and 2 in the hormone-dependent tumor models, a selective, receptor-mediated cytotoxic effect of compound 3 on estrogen-receptor-positive tumors in obvious.

• Authors: M R Schneider, M L Schuderer
• Journal: Journal of cancer research and clinical oncology (J Cancer Res Clin Oncol) Vol. 114 Issue 6 Pg. 583-7 ( 1988) ISSN: 0171-5216 [Print] Germany
• PMID: 3204105 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Alkenes
• Antineoplastic Agents
• Drug Carriers
• Estrogens
• Nitrogen Mustard Compounds
• Receptors, Estrogen
• 1,1-bis(4-(N,N-bis-2-chloroethylcarbamoyloxy)phenyl)-2-phenylbut-1-ene
• 1-(4-(N,N-bis-2-chloroethylcarbamoyloxy)phenyl)-1-(4-hydroxyphenyl)-2-phenylbut-1-ene

Topics

• Alkenes (therapeutic use)
• Animals
• Antineoplastic Agents (therapeutic use)
• Drug Carriers
• Estrogens (therapeutic use)
• Female
• Mammary Neoplasms, Experimental (analysis, drug therapy)
• Mice
• Neoplasms, Hormone-Dependent (drug therapy)
• Nitrogen Mustard Compounds (therapeutic use)
• Receptors, Estrogen (analysis)