Safety of drug use in patients with a primary mitochondrial disease: An international Delphi-based consensus.

Abstract

Clinical guidance is often sought when prescribing drugs for patients with primary mitochondrial disease. Theoretical considerations concerning drug safety in patients with mitochondrial disease may lead to unnecessary withholding of a drug in a situation of clinical need. The aim of this study was to develop consensus on safe medication use in patients with a primary mitochondrial disease. A panel of 16 experts in mitochondrial medicine, pharmacology, and basic science from six different countries was established. A modified Delphi technique was used to allow the panellists to consider draft recommendations anonymously in two Delphi rounds with predetermined levels of agreement. This process was supported by a review of the available literature and a consensus conference that included the panellists and representatives of patient advocacy groups. A high level of consensus was reached regarding the safety of all 46 reviewed drugs, with the knowledge that the risk of adverse events is influenced both by individual patient risk factors and choice of drug or drug class. This paper details the consensus guidelines of an expert panel and provides an important update of previously established guidelines in safe medication use in patients with primary mitochondrial disease. Specific drugs, drug groups, and clinical or genetic conditions are described separately as they require special attention. It is important to emphasise that consensus-based information is useful to provide guidance, but that decisions related to drug prescribing should always be tailored to the specific needs and risks of each individual patient. We aim to present what is current knowledge and plan to update this regularly both to include new drugs and to review those currently included.

• Authors: Maaike C De Vries, David A Brown, Mitchell E Allen, Laurence Bindoff, Gráinne S Gorman, Amel Karaa, Nandaki Keshavan, Costanza Lamperti, Robert McFarland, Yi Shiau Ng, Mar O'Callaghan, Robert D S Pitceathly, Shamima Rahman, Frans G M Russel, Kristin N Varhaug, Tom J J Schirris, Michelangelo Mancuso
• Journal: Journal of inherited metabolic disease (J Inherit Metab Dis) Vol. 43 Issue 4 Pg. 800-818 (Jul 2020) ISSN: 1573-2665 [Electronic] United States
• PMID: 32030781 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
• Copyright: © 2020 The Authors. Journal of Inherited Metabolic Disease published by John Wiley & Sons Ltd on behalf of SSIEM.

Chemical References

• Pharmaceutical Preparations

Topics

• Consensus
• Delphi Technique
• Drug Design
• Drug-Related Side Effects and Adverse Reactions
• Humans
• Internationality
• Mitochondria (drug effects, metabolism)
• Mitochondrial Diseases (chemically induced)
• Pharmaceutical Preparations
• Practice Guidelines as Topic
• Toxicity Tests