[CD20-negative diffuse large B-cell lymphoma complicated by rheumatoid arthritis].

Abstract

CD20 antigen is an important marker for diagnosis of B-cell neoplasms that is highly expressed on the surface of neoplastic B lymphocytes. Patients with rheumatoid arthritis (RA) have an increased risk of developing malignant lymphoma, of which diffuse large B-cell lymphoma (DLBCL) is the most common type. We report an unusual case of CD20-negative DLBCL complicated by rheumatoid arthritis. An 81-year old female presented with a left-sided cervical tumor, enlarged tonsil, and polyarticular pain. Pathological findings of the left tonsil showed proliferation of large atypical cells with irregular shaped nuclei. Most large cells were negative for CD3 and CD20. Additionally, these cells were positive for CD79a, BCL2, and MUM1, and negative for CD10, CD138, BCL6, PAX5, EBV-ISH, HHV8, and ALK.. Therefore, she was diagnosed with CD20-negative DLBCL complicated with RA and received dose-modified CHOP that achieved partial remission. Because CD20-negative DLBCL is rare, the identification of the clinicopathological features of this disease is urgently required.

• Authors: Teruhiko Yoshino, Junya Makiyama, Yoshitaka Imaizumi, Emi Matsuo, Hideaki Kitanosono, Jun Nakashima, Takeharu Kato, Hiroaki Miyoshi, Koichi Ohshima, Shinichiro Yoshida, Yasushi Miyazaki
• Journal: [Rinsho ketsueki] The Japanese journal of clinical hematology (Rinsho Ketsueki) Vol. 61 Issue 1 Pg. 33-38 ( 2020) ISSN: 0485-1439 [Print] Japan
• PMID: 32023600 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antigens, CD20
• Biomarkers
• Neprilysin

Topics

• Aged, 80 and over
• Antigens, CD20
• Arthritis, Rheumatoid (complications)
• Biomarkers
• Female
• Humans
• Lymphoma, Large B-Cell, Diffuse (complications)
• Neprilysin