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Enterococcus: A Predictor of Ravaged Microbiota and Poor Prognosis after Allogeneic Hematopoietic Stem Cell Transplantation.

Abstract
Intestinal flora plays an essential role in regulating immune responses. Changes in the gut flora are associated with poor prognosis after allogeneic hematopoietic stem cell transplantation (HSCT). We aimed to investigate the impact of diverse intestinal flora on survival after allogeneic HSCT. Using next-generation sequencing of the bacterial 16S ribosomal RNA (rRNA) gene, we found that the intestinal microbiota of patients undergoing allogeneic HSCT differed significantly from that of healthy controls. Furthermore, dysbiosis persisted for at least 1 year after transplantation. Interestingly, increased abundance of the genus Enterococcus detected by 16S rRNA sequencing as early as 1 month after transplantation was correlated with poor survival (overall survival at 2 years post-HSCT, 83.9% for patients with <1% relative abundance of Enterococcus and 47.6% for those with ≥1% relative abundance of Enterococcus), which was undetectable by conventional standard stool culture. These findings suggest that detection of Enterococcus by 16S rRNA analysis reflects compromised intestinal flora and may be a promising prognostic indicator.
AuthorsShinsuke Kusakabe, Kentaro Fukushima, Takafumi Yokota, Akihisa Hino, Jiro Fujita, Daisuke Motooka, Shota Nakamura, Hirohiko Shibayama, Yuzuru Kanakura
JournalBiology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation (Biol Blood Marrow Transplant) Vol. 26 Issue 5 Pg. 1028-1033 (05 2020) ISSN: 1523-6536 [Electronic] United States
PMID32018061 (Publication Type: Journal Article)
CopyrightCopyright © 2020 American Society for Transplantation and Cellular Therapy. Published by Elsevier Inc. All rights reserved.
Chemical References
  • RNA, Ribosomal, 16S
Topics
  • Enterococcus (genetics)
  • Gastrointestinal Microbiome
  • Hematopoietic Stem Cell Transplantation
  • Humans
  • Microbiota
  • RNA, Ribosomal, 16S (genetics)

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