Cytogenetics of unfertilized human oocytes.

Abstract

During an in-vitro fertilization programme 150 oocytes from 62 women with a mean age of 31 years (range 24-39) remained unfertilized. Successful chromosome analysis was carried out on 96 oocytes by Q-banding: 59 (61.5%) oocytes bore a normal haploid complement, 8 (8.3%) were diploid and 3 (3.1%) tetraploid. In 26 (27.1%) oocytes aneuploidy was observed; these included 9 (9.4%) nullisomic, 5 (5.2%) double nullisomic, 4 (4.2%) triple nullisomic and 2 (2.1%) disomic oocytes. The remaining 54 (36.0%) oocytes could not be evaluated. A nearly uniform rate of aneuploidy was found for unfertilized oocytes among different donor age groups.

• Authors: M Djalali, B Rosenbusch, M Wolf, K Sterzik
• Journal: Journal of reproduction and fertility (J Reprod Fertil) Vol. 84 Issue 2 Pg. 647-52 (Nov 1988) ISSN: 0022-4251 [Print] England
• PMID: 3199384 (Publication Type: Journal Article)

Topics

• Adult
• Aneuploidy
• Chromosome Mapping
• Female
• Humans
• Infertility, Female (genetics)
• Oocytes (cytology)
• Ploidies