Abstract |
Although the intravenous injection of iodinated contrast media is usually well tolerated by patients, it does cause a significant number of side effects. The current study was designed to determine whether the measurement of peak-expiratory-flow rate before injection of contrast medium can be taken as a predictor of reactions to contrast media. The study covers a population of 100 patients who underwent excretory urography; those with a history of allergy or atopic hypersensitivity were given premedication before contrast injection. Peak-expiratory-flow measurements were made 10 minutes before, and immediately before injection, and at 1 and 15 minutes postinjection by a Wright flow meter. They revealed a subclinical bronchospasm after the intravenous injection of iodinated contrast medium that was more severe for subjects demonstrating an untoward reaction to contrast media. A single measurement of peak expiratory flow 10 minutes before contrast injection is, in itself, a good indicator of increased risk. A patient with a peak expiratory flow of less than 400 L/min 10 minutes before the injection, runs a 3.8 times higher risk of developing an adverse reaction to intravascular radiodiagnostic compounds in this study.
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Authors | P Bertrand, P Rouleau, D Alison, I Chastin |
Journal | Investigative radiology
(Invest Radiol)
Vol. 23 Suppl 1
Pg. S203-5
(Sep 1988)
ISSN: 0020-9996 [Print] United States |
PMID | 3198344
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Bronchial Spasm
(chemically induced)
- Contrast Media
(adverse effects)
- Female
- Forced Expiratory Flow Rates
- Humans
- Hypersensitivity
(immunology)
- Male
- Middle Aged
- Peak Expiratory Flow Rate
- Premedication
- Risk Factors
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