A comparative study of the hepatotoxicity of 1-fluoropentane and 1-fluorohexane.

Abstract

Phenobarbitone pretreatment potentiated hepatocyte lesions in male rats 24 hr after treatment with 1-fluoropentane (3.5 mg/kg body weight) and 1-fluorohexane (0.17 mg/kg body weight). Serum levels of the enzymes ornithine carbamyltransferase, glutamic-pyruvic transaminase and gamma-glutamyltranspeptidase were significantly elevated by the test compounds with the peak effect occurring 24-72 hr after a single ip administration. Significant elevation of hepatocyte triglyceride content and mitochondrial calcium and citrate levels were demonstrated 24 and 48 hr after a single ip injection of 1-fluoropentane or 1-fluorohexane, respectively.

• Authors: C F Nhachi, O Chikuni
• Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association (Food Chem Toxicol) Vol. 26 Issue 8 Pg. 705-13 (Aug 1988) ISSN: 0278-6915 [Print] England
• PMID: 3198037 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Hydrocarbons, Fluorinated
• 1-fluorohexane
• 1-fluoropentane
• Proadifen
• Phenobarbital

Topics

• Animals
• Chemical and Drug Induced Liver Injury
• Drug Synergism
• Hydrocarbons, Fluorinated (toxicity)
• Liver (enzymology, ultrastructure)
• Liver Diseases (enzymology, pathology)
• Male
• Phenobarbital (pharmacology)
• Proadifen (pharmacology)
• Rats
• Rats, Inbred Strains