Localization of the human X-linked gene for chronic granulomatous disease to the mouse X chromosome: implications for X-chromosome evolution.

Abstract

The gene encoded at the human X-linked chronic granulomatous disease locus (cytochrome b245 beta subunit) has been mapped to the mouse X chromosome using an interspecific Mus domesticus x M. spretus cross. The localization of this gene provides detailed information on one of the proposed ancestral breakpoints that account for the divergent evolution of the mouse and human X chromosomes.

• Authors: N Brockdorff, E M Fisher, S H Orkin, M F Lyon, S D Brown
• Journal: Cytogenetics and cell genetics (Cytogenet Cell Genet) Vol. 48 Issue 2 Pg. 124-5 ( 1988) ISSN: 0301-0171 [Print] Switzerland
• PMID: 3197451 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Cytochrome b Group
• DNA Probes
• cytochrome b245

Topics

• Animals
• Biological Evolution
• Chromosome Mapping
• Crosses, Genetic
• Cytochrome b Group (genetics)
• DNA Probes
• Female
• Granulomatous Disease, Chronic (genetics)
• Humans
• Male
• Mice
• Recombination, Genetic
• Sequence Homology, Nucleic Acid
• Sex Chromosome Aberrations (genetics)
• Species Specificity
• X Chromosome