[Antiparasitic activity of Cis-Pt (II) pentamidine in experimental trypanosomiasis of sheep caused by Trypanosoma brucei brucei].

Abstract

The failure of trypanocidal therapeutics have made it a duty to use other classes of molecules which show a comparable trypanocidal efficacy with well-known medicines. In this study, the authors have evaluated the trypanocidal activity of a Cis-Platinum (II) salt, DNA-intercalating medicine used in antineoplastic therapeutics, associated with pentamidine: Cis-Pt (II) pentamidine. After primary screenings on a murine model of T. brucei brucei, Cis-Pt (II) pentamidine was evaluated on an experimental sheep trypanosomiasis model, standardized by the Institute of Neurological Epidemiology and Tropical Neurology of Limoges (France). Cis-Pt (II) pentamidine was able to cure infected mice, without relapse, after a single subcutaneous injection of 12.5 mg.kg-1 body weight. In sheep trypanosomiasis, the same treatment was used successfully during the first stage of infection. Neurological stage susceptibility and pharmacokinetics in sheep will be evaluated in a further study.

• Authors: G Dreyfuss, P Gayral, G Dubost, J A Nicolas, D Craciunescu
• Journal: Bulletin de la Societe de pathologie exotique et de ses filiales (Bull Soc Pathol Exot Filiales) Vol. 81 Issue 3 Pt 2 Pg. 626-31 ( 1988) France
• Vernacular Title: Activité antiparasitaire du Cis-Pt (II) pentamidine dans la trypanosomose expérimentale du mouton à Trypanosoma brucei brucei.
• PMID: 3197258 (Publication Type: English Abstract, Journal Article)

Chemical References

• Amidines
• Organoplatinum Compounds
• Trypanocidal Agents
• platinum(II) pentamidine
• Pentamidine

Topics

• Amidines
• Animals
• Organoplatinum Compounds (therapeutic use)
• Pentamidine (analogs & derivatives, therapeutic use)
• Sheep
• Trypanocidal Agents (therapeutic use)
• Trypanosoma brucei brucei
• Trypanosomiasis, African (drug therapy)