[Trial of pentamidine in the treatment of trypanosomiasis of sheep inoculated with Trypanosoma brucei brucei].

Abstract

An experimental study was carried out using 5 Trypanosoma brucei brucei subcutaneously infected sheep. Pentamidine treatment appeared in the CSF. Two animals were injected daily for 10 days and they died with drug intoxication. Two animals received drug every 3 days for 15 days: one of them died, the other was cured after 3 weeks of set-back. This preliminary study should be completed by experimentation made over a more important period of time.

• Authors: J A Nicolas, C Bosgiraud, G Dubost, M Amevigbe, M Pestre-Alexandre, B Bouteille, M L Darde, J M Vallat, M Dumas
• Journal: Bulletin de la Societe de pathologie exotique et de ses filiales (Bull Soc Pathol Exot Filiales) Vol. 81 Issue 3 Pt 2 Pg. 623-5 ( 1988) France
• Vernacular Title: Essai de la pentamidine dans le traitement de la trypanosomiase du mouton inoculé par Trypanosoma brucei brucei.
• PMID: 3197257 (Publication Type: English Abstract, Journal Article)

Chemical References

• Amidines
• Pentamidine

Topics

• Amidines (therapeutic use)
• Animals
• Pentamidine (therapeutic use)
• Sheep
• Trypanosoma brucei brucei
• Trypanosomiasis, African (drug therapy)