[Treatment of experimental trypanosomiasis of sheep caused by Trypanosoma brucei brucei: efficacy of Ro 15-0216 (a 2-nitroimidazole derivative)].

Abstract

An experiment was carried out on treatment of Trypanosoma brucei brucei experimentally infected sheep with central nervous system involvement with a 2-nitroimidazole derivative: Ro 15-0216 (Hoffmann La Roche & Co Ltd, Basel, Switzerland). After a single intramuscularly or intravenously administration (25 or 50 mg/kg) of this compound in healthy sheep, levels of more than 1 microgram/ml corresponding to trypanocidal concentrations are detected in both blood and cerebrospinal fluid. However, because of short half life, two or three injections a day appeared to be necessary. Six infected sheep were treated by daily intravenous injection for six days: three animals with 25 mg/kg/d and three others with 50 mg/kg/d. Animals which relapsed received 50 mg/kg/d divided in three intravenous injections a day for six days. After a year of observation, all the animals were considered clinically and biologically cured.

• Authors: B Bouteille, M L Darde, M Pestre-Alexandre, M Dumas, J C Breton, J A Nicolas, G Catanzano, M Munoz
• Journal: Bulletin de la Societe de pathologie exotique et de ses filiales (Bull Soc Pathol Exot Filiales) Vol. 81 Issue 3 Pt 2 Pg. 616-22 ( 1988) France
• Vernacular Title: Traitement de la trypanosomiase expérimentale du mouton à Trypanosoma brucei brucei: efficacité du Ro 15-0216 (dérivé 2-nitroimidazolé).
• PMID: 3197255 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Acetanilides
• Nitroimidazoles
• Trypanocidal Agents
• Ro 15-0216

Topics

• Acetanilides (therapeutic use)
• Animals
• Nitroimidazoles (therapeutic use)
• Sheep
• Trypanocidal Agents (therapeutic use)
• Trypanosoma brucei brucei
• Trypanosomiasis, African (drug therapy)