[Anti-arrhythmic and vasodilator actions of the antioxidant fenozan in acute ischemia and reperfusion].

Abstract

At the experiments with the isolated rat hearts, prepared by Langendorff, the anti-arrhythmic dose-effects of the water-soluble antioxidant fenozan from the class of steric-hindrance phenols were studied at condition of regional ischemia and reperfusion, as well as its action on the coronary flow. 3.6.10(-4) M of fenozan completely inhibited ischemic tachycardias, and diminished their incidence during reperfusion to 27%. The action of the fenozan in the concentration one order less, diminished total amount of reperfusion fibrillation to 67% (compared to 100% in control), the incidence of the long fibrillation to 67%, and considerably shifted their beginning to the moment of reperfusion. Dose-effects of anti-arrhythmic action of the antioxidant was V-shaped. Introduction of fenozan before 10 minutes of the occlusion caused an 1.5-2 hold increase of the coronary flow. This data show an effective antiarrhythmic and vasodilator action of the water-soluble phenol antioxidants during acute ischemia and reperfusion of myocardium.

• Authors: L A Vasilets, V P Mokh, L G Plekhanova
• Journal: Biulleten' eksperimental'noi biologii i meditsiny (Biull Eksp Biol Med) Vol. 106 Issue 11 Pg. 554-7 (Nov 1988) ISSN: 0365-9615 [Print] Russia (Federation)
• Vernacular Title: Antiaritmicheskoe i vazodilatornoe deĭstvie antioksidanta fenozana pri ostroĭ ishemii i referfuzii.
• PMID: 3196853 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Anti-Arrhythmia Agents
• Antioxidants
• Phenylpropionates
• Vasodilator Agents
• fenozan

Topics

• Animals
• Anti-Arrhythmia Agents (pharmacology, therapeutic use)
• Antioxidants (pharmacology, therapeutic use)
• Coronary Disease (drug therapy, physiopathology)
• Coronary Vessels (drug effects)
• Dose-Response Relationship, Drug
• Drug Evaluation, Preclinical
• In Vitro Techniques
• Male
• Phenylpropionates (pharmacology, therapeutic use)
• Rats
• Vascular Resistance (drug effects)
• Vasodilator Agents (pharmacology, therapeutic use)