Effects of cisplatin on parathyroid hormone- and human lung tumor-induced bone resorption.

Abstract

We have previously shown that dichlorodiamine platinum (DDP), or cisplatin, a cancer chemotherapeutic agent, is effective in the treatment of malignancy-associated hypercalcemia. In the present studies, we evaluated its effects on bovine parathyroid hormone (PTH)- or tumor-induced bone resorption in vitro in the neonatal mouse calvarial bone resorption assay. PTH alone or tumor extract (TE) of a human squamous cell lung cancer alone caused a significant increase in the bone resorption and in the number of osteoclasts in the calvaria. The addition of 3 and 10 micrograms/ml DDP inhibited the PTH- or TE-induced bone resorption. Lower doses of 1 and 2 micrograms/ml DDP, although not effective in inhibiting the PTH-induced bone resorption, were effective in lowering the TE-induced bone resorption. The number of osteoclasts was also reduced by DDP treatment. We therefore conclude that DDP is effective in the treatment of malignancy-associated hypercalcemia by virtue of its inhibitory effects on osteoclast numbers and on bone resorption.

• Authors: E C Abramson, J Chang, M Mayer, L J Kukla, D H Shevrin, T E Lad, R Buschman, S C Kukreja
• Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research (J Bone Miner Res) Vol. 3 Issue 5 Pg. 541-6 (Oct 1988) ISSN: 0884-0431 [Print] United States
• PMID: 3195366 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Parathyroid Hormone
• Cisplatin

Topics

• Animals
• Bone Resorption (drug effects)
• Cattle
• Cisplatin (pharmacology)
• Humans
• Lung Neoplasms (physiopathology)
• Mice
• Microscopy, Electron
• Neoplasm Transplantation
• Parathyroid Hormone (physiology)