Wilms tumor is considered to be the most common renal
malignancy among children. RAN, a member of RAS superfamily, and its binding partner
RANBP2 are related to the progression of multiple
tumors. Nevertheless, the effects of the RAN and
RANBP2 gene polymorphisms on the
tumorigenesis of
Wilms tumor remain unclarified. In this study, three potentially functional polymorphisms (rs56109543 C>T, rs7132224 A>G, and rs14035 C>T) in the RAN and one (rs2462788 C>T) in the
RANBP2 were chosen to investigate their association with
Wilms tumor susceptibility. Odds ratios (
ORs) and 95% confidence intervals (CIs) were applied to assess the association of the selected polymorphisms with
Wilms tumor susceptibility. Results shown that RAN rs7132224 AG/GG genotypes significantly increased
Wilms tumor risk when compared to AA genotype (adjusted OR=1.40, 95% CI=1.01-1.95, P=0.047). Carriers of 1-3 risk genotypes have a significantly higher
Wilms tumor risk than those without risk genotype (adjusted OR=1.49, 95% CI=1.07-2.07, P=0.020). Moreover, stratified analysis indicated that RAN rs56109543 CT/TT genotypes, RAN rs7132224 AG/GG genotypes and
RANBP2 rs2462788 CT/TT genotypes remarkably increased
Wilms tumor susceptibility among the subgroups. Our results indicated that RAN and
RANBP2 polymorphisms were associated with
Wilms tumor susceptibility in Chinese children. The role of RAN/
RANBP2 in
cancers deserves more attention.