Abstract |
We report two patients with multiple sclerosis which illustrate problems in the interpretation of the cerebrospinal fluid (CSF) protein studies used to confirm diagnosis. In one case a polyclonal increase in IgG synthesis, secondary to an aseptic meningitis, masked oligoclonal banding, which was confirmed on subsequent examination. In the second case, despite a normal quantitative intrathecal IgG synthesis rate, oligoclonal banding in the CSF confirmed abnormal intrathecal synthesis of IgG. These cases show the value of combining a quantitative index of intrathecal IgG synthesis with examination for oligoclonal banding and illustrate their interpretation.
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Authors | J M Sheat, P M George, I M Donaldson |
Journal | The New Zealand medical journal
(N Z Med J)
Vol. 101
Issue 858
Pg. 790-2
(Nov 23 1988)
ISSN: 0028-8446 [Print] New Zealand |
PMID | 3194076
(Publication Type: Case Reports, Journal Article)
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Chemical References |
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Topics |
- Adult
- Electrophoresis, Agar Gel
- Female
- Humans
- Immunoglobulin G
(biosynthesis)
- Multiple Sclerosis
(blood, cerebrospinal fluid)
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