Effects of the calcium antagonist NB-818 on cerebral blood flow.

Abstract

The effects of intravenous injection of NB-818, isopropyl methyl 2-carbamoyloxymethyl-6-methyl-4-(2,3-dichlorophenyl)-1,4-dihydropyridine-3,5- dicarboxylate, on regional cerebral blood flow were studied in rabbits and Rhesus monkeys, using the hydrogen clearance technique. The above effects were compared with those of nicardipine and nimodipine. In rabbits, NB-818 (10 micrograms/kg i.v.) increased both cerebral cortical blood flow (rCBF) and cerebellar cortical blood flow by about 80% of the predrug level with a moderate decrease in mean arterial blood pressure, and no increase in skeletal muscle blood flow. The increase in cerebral blood flow with NB-818 was as great as that with nicardipine or nimodipine. In Rhesus monkeys, NB-818 (10-20 micrograms/kg i.v.) increased rCBF by about 30% of the predrug level, and its effect continued 30-60 min after dosing. The increase in rCBF with NB-818 was greater than that with nicardipine. The results from the present study indicate that NB-818 predominantly increases rCBF with a concomitant moderate hypotension, and its action is greater than that of nicardipine or nimodipine.

• Authors: M Nishikibe, A Nakajima
• Journal: Life sciences (Life Sci) Vol. 43 Issue 21 Pg. 1715-23 ( 1988) ISSN: 0024-3205 [Print] Netherlands
• PMID: 3193855 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Calcium Channel Blockers
• Dihydropyridines
• Nimodipine
• NPK 1886
• Nicardipine

Topics

• Animals
• Blood Pressure (drug effects)
• Calcium Channel Blockers (pharmacology)
• Cerebrovascular Circulation (drug effects)
• Dihydropyridines (pharmacology)
• Heart Rate (drug effects)
• Macaca mulatta
• Male
• Nicardipine (pharmacology)
• Nimodipine (pharmacology)
• Rabbits
• Reference Values
• Species Specificity