Abstract | BACKGROUND: METHODS: This study aims to compare oncological safety of OBCS with SBCS and mastectomy by examining the relative risk of cancer recurrence and re-operation rates through meta-analysis. RESULTS: 18 studies met the search criteria including 18,103 patients. The primary outcome measure (recurrence) was not significantly different between OBCS and SBCS or mastectomy (RR 0.861; 95% CI 0.640-1.160; p = 0.296). The secondary outcome measure (re-operation) initially achieved significance in favour of OBCS (RR 0.64; 95% CI 0.46-0.89; p = 0.01). However, after adjustment for publication bias this was attenuated to insignificance between the two study groups (RR 0.86; 95% CI 0.56-1.31; p = 0.44). CONCLUSIONS: For both cancer recurrence and re-operation rate, there was no significant difference between OBCS and traditional techniques. OBCS is of comparable oncological safety to more established surgical procedures and a useful option in suitable patients.
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Authors | Sebastian Kosasih, Salim Tayeh, Kefah Mokbel, Abdul Kasem |
Journal | American journal of surgery
(Am J Surg)
Vol. 220
Issue 2
Pg. 385-392
(08 2020)
ISSN: 1879-1883 [Electronic] United States |
PMID | 31926592
(Publication Type: Journal Article, Meta-Analysis)
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Copyright | Copyright © 2020 Elsevier Inc. All rights reserved. |
Topics |
- Breast Neoplasms
(surgery)
- Female
- Humans
- Mastectomy, Segmental
(adverse effects)
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