Inhibitory effect of FK-565 alone and in combination with zidovudine on retroviral infection by Friend leukemia virus in mice.

Abstract

The effects of route and starting time of administration on FK-565 inhibition of splenomegaly by Friend leukemia virus (FLV) were studied in mice, and the concomitant effect of FK-565 in allowing reduction of zidovudine dosage was estimated. FK-565 inhibited splenomegaly in intravenous and oral doses of 0.01 to 1 mg/kg, but time of initial dosing had little effect on this inhibition. When 0.01 or 1 mg/kg of FK-565 was given intravenously with intraperitoneal doses of 0.63, 2.5, 10 and 40m g/kg of zidovudine, the inhibition rate of splenomegaly at all doses was markedly and dose-dependently higher than when either drug was given alone, and the concomitant use of FK-565 with zidovudine enabled a 16-fold reduction of the dose of zidovudine. The survival rate and survival time after infection with massive amounts of FLV were higher when FK-565 1 mg/kg and zidovudine 20 mg/kg were given in combination than when either drug was given alone. Inhibition of FLV splenomegaly was reflected in the prolonged survival time of the infected mice.

• Authors: Y Yokota, Y Wakai, Y Watanabe, Y Mine
• Journal: The Journal of antibiotics (J Antibiot (Tokyo)) Vol. 41 Issue 10 Pg. 1479-87 (Oct 1988) ISSN: 0021-8820 [Print] England
• PMID: 3192497 (Publication Type: Journal Article)

Chemical References

• Oligopeptides
• Zidovudine
• heptanoyl-gamma-D-glutamyl-L-meso-diaminopimelyl-D-alanine

Topics

• Animals
• Cell Survival (drug effects)
• Dose-Response Relationship, Drug
• Drug Therapy, Combination
• Friend murine leukemia virus (drug effects)
• Leukemia, Experimental (drug therapy)
• Male
• Mice
• Mice, Inbred C3H
• Oligopeptides (administration & dosage, pharmacology)
• Virus Replication (drug effects)
• Zidovudine (administration & dosage, pharmacology)