An experimental evaluation of response to contrast media: Pantopaque, iopamidol, and iohexol in the subarachnoid space.

Abstract

Myelography in dogs was performed with Pantopaque, iopamidol and iohexol. The effects of these agents were evaluated by histologic study of the brain, spinal cord, and meninges four months after the procedure. Retained Pantopaque was always accompanied by some degree of arachnoidal reaction, mild in the cervical cord segment and severe in the most caudal part of the cul-de-sac. No apparent protection against Pantopaque arachnoiditis was provided by either intrathecal or intramuscular methylprednisolone. We found no histologic evidence of arachnoiditis in animals examined with iopamidol and iohexol.

• Authors: A Paşaoğlu, A Gök, T E Patiroğlu
• Journal: Investigative radiology (Invest Radiol) Vol. 23 Issue 10 Pg. 762-6 (Oct 1988) ISSN: 0020-9996 [Print] United States
• PMID: 3192397 (Publication Type: Journal Article)

Chemical References

• Contrast Media
• Iodobenzenes
• Iohexol
• Iophendylate
• Iopamidol
• Methylprednisolone

Topics

• Animals
• Brain (drug effects)
• Contrast Media (administration & dosage, toxicity)
• Dogs
• Injections, Spinal
• Iodobenzenes (toxicity)
• Iohexol (administration & dosage, toxicity)
• Iopamidol (administration & dosage, toxicity)
• Iophendylate (administration & dosage, antagonists & inhibitors, toxicity)
• Meninges (drug effects)
• Methylprednisolone (therapeutic use)
• Spinal Cord (drug effects)
• Subarachnoid Space (drug effects)