Abstract |
We have measured plasma and synovial fluid concentrations of meclofenamic acid at 2, 4, 8, and 12 h during steady-state administration (100 mg three times daily for 4-7 days). Paired plasma and synovial samples were obtained pre-treatment and at one of the above times in twelve patients with a diagnosis of rheumatoid arthritis. In addition, the extent of protein binding of meclofenamic acid was assessed in vitro in the pre-treatment plasma and synovial fluid specimens. Peak total concentrations of 1.73 and 0.86 micrograms.ml-1 were observed in plasma (at 2 h) and synovial fluid (at 4 h) respectively. The extent of protein binding was 99.7 and 99.6% (not significantly different) in plasma and synovial fluid respectively. The results of this study are compared to those from similar reported studies of other nonsteroidal anti-inflamatory compounds.
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Authors | J R Koup, D Thomas, E Tucker, A Black, M Ruderman, J A Dixon, A Kinkel |
Journal | European journal of clinical pharmacology
(Eur J Clin Pharmacol)
Vol. 35
Issue 2
Pg. 199-202
( 1988)
ISSN: 0031-6970 [Print] Germany |
PMID | 3191939
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- ortho-Aminobenzoates
- Meclofenamic Acid
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Topics |
- Arthritis, Rheumatoid
(drug therapy, metabolism)
- Female
- Humans
- Knee Joint
- Male
- Meclofenamic Acid
(administration & dosage, analysis, blood)
- Middle Aged
- Protein Binding
- Synovial Fluid
(analysis)
- ortho-Aminobenzoates
(analysis)
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