RETRACTED: LncRNA DANCR silence inhibits SOX5-medicated progression and autophagy in osteosarcoma via regulating miR-216a-5p.

Abstract

This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of the Authors and Editor-in-Chief. The authors of this article have informed the editors that the human anti-LC3 antibody used in this work recognized multiple antigens in murine tissues, leading them to believe that the antibody is contaminated. This possible contamination further leads them to determine that the data generated using these antibodies, and any conclusions based on that data, cannot be considered accurate. Furthermore, the authors also report that subsequent work has revealed that the DANCR/miR-216a-5p axis plays a role in the regulation of beta-oxidation and downstream non-programmed cell death and homeostasis. They therefore have requested to retract this article as unreliable. The authors have not provided the relevant raw data for the editors' review, or the subsequent reported role of DANCR in beta-oxidation. Therefore, given the authors' loss of confidence in these findings, the Editor-in-Chief supports the decision to retract the article.

• Authors: Zhengxia Pan, Chun Wu, Yonggang Li, Hongbo Li, Yong An, Gang Wang, Jiangtao Dai, Quan Wang
• Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie (Biomed Pharmacother) Vol. 122 Pg. 109707 (02 2020) ISSN: 1950-6007 [Electronic] France
• PMID: 31918278 (Publication Type: Journal Article, Retracted Publication)
• Copyright: Copyright © 2019 The Authors. Published by Elsevier Masson SAS.. All rights reserved.

Chemical References

• Biomarkers, Tumor
• DANCR long noncoding RNA, human
• MIRN216 microRNA, human
• MicroRNAs
• RNA, Long Noncoding
• SOX5 protein, human
• SOXD Transcription Factors

Topics

• Animals
• Apoptosis (genetics)
• Autophagy
• Biomarkers, Tumor (genetics)
• Bone Neoplasms (genetics, pathology)
• Cell Line, Tumor
• Cell Proliferation (genetics)
• Disease Progression
• Down-Regulation (genetics)
• Gene Expression Regulation, Neoplastic (genetics)
• Humans
• Male
• Mice
• Mice, Inbred BALB C
• Mice, Nude
• MicroRNAs (genetics)
• Osteosarcoma (genetics, pathology)
• Prognosis
• RNA, Long Noncoding (genetics)
• SOXD Transcription Factors (genetics)