Abstract | PURPOSE: METHODS: This single-center retrospective observational study was performed by reviewing the medical records of children below 7 years old with epilepsy and were treated with perampanel. RESULTS: A total 38 patients (19 females, 19 males) were enrolled, with a mean age of 4 ± 1.6 years (range, 0-6 years). The response rates (defined as 50 % seizure reduction) were 44 % and 31 % after 6 and 12 months of treatment, respectively, and the freedom of seizures was reached in 13 % and 10 % after the same treatment periods. The short- and long-term response rate in patients with tuberous sclerosis ( TSC) and Dravet syndrome was high (67 %). The response rate in refractory spasms was 40 % at 6 months, but dropped to 13 % after 12 months of treatment. The retention rates were 61.1 % and 51.5 % at 6 and 12 months, respectively. Adverse events were reported in eight patients (22 %), which included emotional change (n = 4), lethargy (n = 2), nasal bleeding (n = 1), and drug allergy (n = 1). CONCLUSIONS:
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Authors | Fu-Man Chang, Pi-Chaun Fan, Wen-Chin Weng, Chin-Hao Chang, Wang-Tso Lee |
Journal | Seizure
(Seizure)
Vol. 75
Pg. 82-86
(Feb 2020)
ISSN: 1532-2688 [Electronic] England |
PMID | 31901668
(Publication Type: Journal Article, Observational Study)
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Copyright | Copyright © 2019 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved. |
Chemical References |
- Anticonvulsants
- Nitriles
- Pyridones
- perampanel
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Topics |
- Adolescent
- Anticonvulsants
(therapeutic use)
- Child
- Child, Preschool
- Drug Resistant Epilepsy
(diagnosis, drug therapy)
- Female
- Humans
- Infant
- Infant, Newborn
- Male
- Nitriles
- Pyridones
(therapeutic use)
- Retrospective Studies
- Treatment Outcome
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