[Experimental and clinical study of the effectiveness of the combined use of anticonvulsants and tranquilizers in epilepsy].

Abstract

Using experimental and clinical methods, the authors studied the efficacy of combined use of anticonvulsants (phenobarbital, hexamidine, chloracon, trimetin, benzonal, diphenylhydantoin, carbamazepine) and tranquilizers (diazepam, chlordiazepoxide, meprotan, trioxazine, mebicar) in epilepsy treatment. The experimental findings showed that 13 combinations of the above drugs had a synergic effect. Five of these combinations (hexamidine-chlordiazepoxide, benzonal-chlordiazepoxide, phenobarbital-diazepam, phenobarbital-trioxazine, and phenobarbital-mebicar also proved clinically more effective than the use of anticonvulsants alone.

• Authors: V S Zalesov, T I Prostakova, E A Khvolis, A A Shutov
• Journal: Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952) (Zh Nevropatol Psikhiatr Im S S Korsakova) Vol. 88 Issue 6 Pg. 53-6 ( 1988) ISSN: 0044-4588 [Print] Russia (Federation)
• Vernacular Title: Eksperimental'noe i klinicheskoe izuchenie éffektivnosti kombinirovannogo primeneniia antikonvul'santov i trankvilizatorov pri épilepsii.
• PMID: 3188750 (Publication Type: English Abstract, Journal Article)

Chemical References

• Anticoagulants
• Tranquilizing Agents

Topics

• Adolescent
• Adult
• Animals
• Anticoagulants (therapeutic use, toxicity)
• Dogs
• Drug Evaluation
• Drug Evaluation, Preclinical
• Drug Synergism
• Drug Therapy, Combination
• Drug Tolerance
• Epilepsy (drug therapy)
• Female
• Humans
• Male
• Mice
• Middle Aged
• Rats
• Seizures (drug therapy)
• Tranquilizing Agents (therapeutic use, toxicity)