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[Cerebrovascular incidents in 4 hemodialysis patients treated with erythropoietin].

Abstract
Human recombinant erythropoietin (r-huEPO) is very effective in the treatment of anemia of hemodialyzed patients. We describe 4 patients who developed symptoms of central nervous dysfunction during r-huEPO therapy. Three exhibited typical hypertensive encephalopathy, whereas signs of cerebral ischemia were found in the fourth. The increase in blood viscosity with r-huEPO treatment, leading to a rise in peripheral vascular resistance and blood pressure especially in previously hypertensive patients, may be of importance in the pathogenesis of these cerebrovascular incidents; preexistent arteriosclerosis is an possible additional risk factor.
AuthorsC Zehnder, A Blumberg
JournalSchweizerische medizinische Wochenschrift (Schweiz Med Wochenschr) Vol. 118 Issue 40 Pg. 1423-6 (Oct 08 1988) ISSN: 0036-7672 [Print] Switzerland
Vernacular TitleZerebrovaskuläre Ereignisse bei vier mit Erythropoietin behandelten Hämodialysepatienten.
PMID3187475 (Publication Type: Case Reports, English Abstract, Journal Article)
Chemical References
  • Recombinant Proteins
  • Erythropoietin
Topics
  • Adult
  • Aged
  • Anemia, Hemolytic (etiology, therapy)
  • Blood Viscosity (drug effects)
  • Brain Edema (chemically induced)
  • Brain Ischemia (chemically induced)
  • Cerebrovascular Disorders (chemically induced)
  • Erythropoietin (adverse effects, therapeutic use)
  • Female
  • Humans
  • Male
  • Middle Aged
  • Recombinant Proteins (adverse effects)
  • Renal Dialysis (adverse effects)

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