| Abstract | Human recombinant erythropoietin (r-huEPO) is very effective in the treatment of anemia of hemodialyzed patients. We describe 4 patients who developed symptoms of central nervous dysfunction during r-huEPO therapy. Three exhibited typical hypertensive encephalopathy, whereas signs of cerebral ischemia were found in the fourth. The increase in blood viscosity with r-huEPO treatment, leading to a rise in peripheral vascular resistance and blood pressure especially in previously hypertensive patients, may be of importance in the pathogenesis of these cerebrovascular incidents; preexistent arteriosclerosis is an possible additional risk factor. |
| Authors | C Zehnder, A Blumberg
(Affiliation: Medizinische Klinik, Abteilung Nephrologie, Kantonsspital Aarau.)
|
| Journal | Schweizerische medizinische Wochenschrift
(Schweiz Med Wochenschr)
Vol. 118
Issue 40
Pg. 1423-6
(Oct 8 1988)
ISSN: 0036-7672 SWITZERLAND |
| Vernacular Title | Zerebrovaskuläre Ereignisse bei vier mit Erythropoietin behandelten Hämodialysepatienten. |
| PMID | 3187475
(Publication Type: Case Reports, English Abstract, Journal Article)
|
| Chemical References |
- Recombinant Proteins
- Erythropoietin
|
| Topics |
- Adult
- Aged
- Anemia, Hemolytic
(etiology, therapy)
- Blood Viscosity
(drug effects)
- Brain Edema
(chemically induced)
- Brain Ischemia
(chemically induced)
- Cerebrovascular Disorders
(chemically induced)
- Erythropoietin
(adverse effects, therapeutic use)
- Female
- Humans
- Male
- Middle Aged
- Recombinant Proteins
(adverse effects)
- Renal Dialysis
(adverse effects)
|
