Diagnostic Performance of Serum Asialo-α1-acid Glycoprotein for Advanced Liver Fibrosis or Cirrhosis in Patients with Chronic Hepatitis B or Nonalcoholic Fatty Liver Disease.

Abstract

BACKGROUND/AIMS:

The utility of asialo-α1-acid glycoprotein (AsAGP) for assessing the fibrotic burden is unknown. This study examined the diagnostic performance of the AsAGP level for advanced liver fibrosis or cirrhosis in patients with chronic hepatitis B (CHB) or nonalcoholic fatty liver disease (NAFLD).

METHODS:

From July to December 2018, 48 patients with CHB and 75 with NAFLD were recruited prospectively. Transient elastography was used as the reference standard for liver fibrosis, and the cutoff liver stiffness values were defined as 10.0 kilopascal (kPa) for ≥F3 and 12.0 kPa for F4 in CHB patients, and 9.0 kPa for ≥F3 and 11.8 kPa for F4 in NAFLD patients.

RESULTS:

To predict stage ≥F3 and F4 fibrosis, the areas under the receiver operating characteristic curves of the AsAGP level in patients with CHB were 0.788 (95% CI 0.647-0.930; p=0.005) and 0.825 (95% CI 0.674-0.976; p=0.004), respectively. The cutoff AsAGP levels in patients with CHB that maximized the sum of the sensitivity and specificity values were 1.31 (sensitivity 100.0%, specificity 52.6%) and 1.55 (sensitivity 75.0%, specificity 80.0%), respectively. In contrast, the AsAGP level was similar regardless of the fibrosis stage in patients with NAFLD (all p>0.05 between the stages).

CONCLUSIONS:

The AsAGP level showed acceptable diagnostic accuracy in predicting advanced liver fibrosis and cirrhosis in patients with CHB but not in those with NAFLD. Further studies will be needed to validate the diagnostic performance of the AsAGP level in patients with NALFD.

• Authors: Seung Up Kim, Mi Young Jeon, Tae Seop Lim
• Journal: The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi (Korean J Gastroenterol) Vol. 74 Issue 6 Pg. 341-348 (Dec 25 2019) ISSN: 2233-6869 [Electronic] Korea (South)
• PMID: 31870140 (Publication Type: Journal Article)

Chemical References

• Asialoglycoproteins
• Orosomucoid
• asialoorosomucoid

Topics

• Adult
• Area Under Curve
• Asialoglycoproteins (blood)
• Elasticity Imaging Techniques
• Female
• Hepatitis B, Chronic (complications)
• Humans
• Liver (physiopathology)
• Liver Cirrhosis (complications, diagnosis, pathology)
• Male
• Middle Aged
• Non-alcoholic Fatty Liver Disease (complications)
• Odds Ratio
• Orosomucoid (analogs & derivatives)
• ROC Curve
• Sensitivity and Specificity
• Severity of Illness Index