Ultra-Early Diagnosis of Acute Myocardial Infarction in Rats Using Ultrasound Imaging of Hollow Double-Layer Silica Nanospheres.

Abstract

Timely diagnosis of acute myocardial infarction (AMI) strongly impacts the survival rate of patients. The authors report the development of a two-shell hollow silica contrast agent useful for ultrasound (US) imaging, which is able to provide ultra-early diagnosis of AMI. To target the characterization of fast blood flow and high blood pressure in the heart, two shells of hollow silica are adopted with opposite polarities, which assemble based on amino and perfluorodecyl silanes. The external amino silane facilitates the attachment of disease-targeted groups, while the internal perfluorodecyl silane provides great US imaging contrast. The material also possesses superior water dispersity, controllable morphology, low toxicity, and biodegradability both in vitro and in vivo, thus promoting its applications in the ultra-early diagnosis of AMI in rats, and is particularly useful for delineation of myocardial necrosis sites.

• Authors: Mengzhe Guo, Wencheng Du, Nan Lyu, Xi Chen, Yan Du, Haibo Wang, Dongzhi Yang, Shihua Wu, Jun Liang, Yuanjiang Pan, Daoquan Tang
• Journal: Advanced healthcare materials (Adv Healthc Mater) Vol. 9 Issue 3 Pg. e1901155 (02 2020) ISSN: 2192-2659 [Electronic] Germany
• PMID: 31867893 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Chemical References

• CY5.5 cyanine dye
• Carbocyanines
• Contrast Media
• Silicon Dioxide
• Fluorescein-5-isothiocyanate

Topics

• Animals
• Carbocyanines (chemistry)
• Cell Line
• Cell Survival (drug effects)
• Contrast Media (chemical synthesis, chemistry)
• Early Diagnosis
• Female
• Fluorescein-5-isothiocyanate (chemistry)
• Hemolysis (drug effects)
• Male
• Mice
• Microscopy, Electron, Transmission
• Myocardial Infarction (diagnostic imaging)
• Nanospheres (chemistry, therapeutic use)
• Rats, Sprague-Dawley
• Silicon Dioxide
• Spectroscopy, Fourier Transform Infrared
• Ultrasonography (instrumentation, methods)