Clinical study of a patient with lupus vulgaris before and after injection of dialyzable transfer factor.

Abstract

This report describes the clinical improvement and acquisition of tuberculin skin-test sensitivity by a tuberculin-negative, drug-resistant patient with lupus vulgaris after a single injection of dialyzable transfer factor (TFd) from a tuberculin-positive healthy donor. The patient's lymphocytes showed a slight response to tuberculin in the leukocyte migration inhibition test and in the lymphocyte transformation test before TFd injection. The acquisition of cellular immunity to tuberculin was demonstrated in vitro by enhanced tuberculin-induced blast transformation. A good correlation between skin test and in vitro tuberculin sensitivity and clinical improvement was seen during the three years that the patient was observed.

• Authors: M Horsmanheimo, K Krohn, M Virolainen
• Journal: The Journal of investigative dermatology (J Invest Dermatol) Vol. 68 Issue 1 Pg. 10-5 (Jan 1977) ISSN: 0022-202X [Print] United States
• PMID: 318672 (Publication Type: Case Reports, Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Macrophage Migration-Inhibitory Factors
• Transfer Factor

Topics

• Adult
• Dialysis
• Humans
• Lupus Vulgaris (drug therapy, immunology)
• Lymphocyte Activation
• Macrophage Migration-Inhibitory Factors
• Male
• Middle Aged
• Skin Tests
• Transfer Factor (therapeutic use)
• Tuberculin Test